Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.
|
30003372 |
2018 |
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings support the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility, suggesting a modulation of stroke risk by a genetic main effect and gene-gene interactions.
|
26159646 |
2015 |
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four new susceptibility genes have been identified using genome-wide association studies or genome-wide linkage studies: LTA (encoding cytokine lymphotoxin-alpha) on 6p21.3 for MI; LGALS2 (encoding galectin-2, an LTA-interacting protein) on 22q12-q13 for MI; ALOX5AP (encoding 5-lipoxygenase activating protein involved in synthesizing potent pro-inflammatory leukotrienes) on 13q12-13 for MI and stroke; and PDE4D (encoding phosphodiesterase 4D) on 5q12 for ischemic stroke.
|
15811259 |
2005 |
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the association of common genetic variation in prostaglandin H synthase 1 (PTGS1), prostaglandin H synthase 2 (PTGS2), thromboxane A2 synthase (TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase (ALOX15) with the risks of myocardial infarction (MI) and ischemic stroke.
|
19046748 |
2009 |
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies that employ genome-wide linkage scans with hundreds of small nuclear families have identified new susceptibility genes for coronary artery disease and myocardiaI infarction, including ALOX5AP (encoding 5-lipoxygenase-activating protein) associated with myocardial infarction and stroke and PDE4D (encoding phosphodiesterase 4D) for ischemic stroke.
|
15861005 |
2005 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further assess the contribution of the ALOX5AP variants to cardiovascular diseases in a population outside Iceland, we genotyped seven single-nucleotide polymorphisms that define both HapA and HapB from 450 patients with ischemic stroke and 710 controls from Aberdeenshire, Scotland.
|
15640973 |
2005 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 10 specific Icelandic ALOX5AP gene variants among 600 male participants with incident atherothrombotic events (myocardial infarction [MI] or ischemic stroke) and among 600 age- and smoking-matched male participants, all white, who remained free of reported cardiovascular disease during follow-up within the Physicians' Health Study cohort.
|
16778124 |
2006 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.
|
29096760 |
2017 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.
|
25534367 |
2015 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we report significant association of variants of ALOX5AP with ischemic stroke and ischemic stroke subtypes among whites.
|
17387518 |
2007 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the association between the risk of ischemic stroke and single-nucleotide polymorphisms (SNPs) in the ALOX5AP and PDE4D genes in a southeastern Chinese population.
|
24485247 |
2015 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no statistically significant association of ALOX5AP rs4073259 SNP with ischemic stroke in this northeastern Chinese Han population living in Heilongjiang province, China.
|
24635928 |
2014 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3'UTR).
|
21816595 |
2011 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALOX5AP SG13S114 polymorphism is associated with susceptibility to IS in Chinese population.
|
24148560 |
2014 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence of association between variants of ALOX5AP and ischemic stroke.
|
16130105 |
2005 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP gene is associated with decreased risk of ischemic stroke in two independent Chinese populations.
|
25815512 |
2015 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous Icelandic studies reported that single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) region and the 5-lipoxygenase activating protein ALOX5AP were associated with ischaemic stroke, whereas other studies reported ambiguous findings.
|
18398440 |
2008 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we found no evidence of association between PDE4D and ALOX5AP genes and the risk of IS in a genetically homogenous population from Sardinia.
|
19417766 |
2009 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest the ALOX5AP SNP A allele in rs4073259 and genotype rs9579646 GG, rs9551963 AC, and haplotype rs9315050 & rs9551963 AAAC were associated with an increased risk of ischemic stroke in the Han population, while rs4073259 GG was associated with a decreased risk.
|
22849376 |
2012 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, combined analysis indicated that AA genotype of ALOX5AP SG13S114A/T was significantly associated with increased risk of IS incidence compared with TT genotype [OR and 95%CI: 1.47 (1.13-1.91), P=0.005].
|
24183033 |
2014 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A first meta-analysis of both subsets showed that the T allele of the SG13S114 SNP in ALOX5AP was a risk factor for IS after Bonferroni correction [OR = 1.22 (1.06-1.40); p = 0.006].
|
20357438 |
2010 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To conclude, SG13S114/AA of the ALOX5AP gene was associated with an increased risk for IS.
|
24198186 |
2014 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated genetic variants in the promoter region of the ALOX5AP gene and the association with ischemic stroke in a north Chinese Han population.
|
21893978 |
2011 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Generalized multifactor dimensionality reduction (GMDR) analysis revealed that the combination of ALOX5 rs10900213, ALOX5AP rs4293222 and MPO rs2107545 was significantly associated with increased risk of ischemic stroke (P=0.0040, OR (95% CI) =1.991 (1.241 to 3.195)).
|
29041000 |
2017 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis suggested that the A allele at the ALOX5AP SG13S114 polymorphism is a protective factor for the IS in the Europeans.
|
28101761 |
2017 |